Brazil has asked FIFA to impose the five-day rule, which means that at least eight Premier League players will be unavailable for selection this weekend.
Manchester City, Leeds, Liverpool, Chelsea, and Manchester United are among the clubs affected, according to the UK Mirror.
For their match against Leeds on Sunday, Liverpool will be without Becker Alisson, Roberto Firmino, and Fabinho.
Raphinha will also be absent from Marcelo Bielsa’s squad.
Gabriel Jesus and Ederson will miss Manchester City’s match against Leicester City on Saturday.
Thiago Silva of Chelsea and Fred of Manchester United are also affected.
The Premier League clubs faced a FIFA penalty after raising concerns about players traveling for international duty while under the tight COVID-19 requirements in the United Kingdom.
Those arriving in the UK from countries on the red list must spend 10 days in isolation.